… and ‘de-activates’ factors that inhibit The majority of acute and chronic Box 1: How HydroClean® plus works wound healing (e.g. excessive levels of wounds can be treated with (Ousey et al, 2016b) proteinases) (Ousey et al, 2016b) (Box 1). … This level reduced to 4% after 1 month of treatment In a 20-patient study of chronic wounds, >50% of patients reported a reduction in wound exudate levels between initial and fi nal assessment (mean 15 days) and there was an increase in percentage of patients with healthy periwound skin from 25% to 55% In a 270-patient observational study in patients with a variety of wounds, irritation of peri- lesional skin over an average of 9 days was reduced from 71% to 46% Granulation tissue In a 75-patient, observational, comparative study in patients with ulcers, there was an absolute Humbert et al, 2014; formation increase in the proportion of ulcer area covered by granulation tissue of 36%, compared with HARTMANN, 2010; only 14.5% in the comparative group (hydrogel) König et al, 2005; Kaspar et al, 2008 In a 403-patient observational study in patients with a variety of ulcers, the proportion of wounds >50% fi lled with granulation tissue increased from 6% to 69% during the treatment period (average: 1 month) In a 42-patient RCT in chronic leg ulcers, there was a 26% increase in granulation tissue in the HRWD treatment group compared with an increase of only 10% in the comparative group (enzymatic preparation) over the course of 14 days’ treatment In a 221-patient observational study in patients with chronic wounds, the number of wounds showing granulation tissue (>50% surface area) increased from 5% to 74% over the course of the 1-month treatment period Epithelialisation In 270-patient observational study in patients with a variety of hard-to-heal wounds where the Smola et al, 2016b wound bed consisted mostly of granulation tissue, the proportion of epithelial tissue over the course of the observation period (three dressing changes) increased from 16% to 28% Reduced pain In a 37-patient observational study in patients with venous leg ulcers, 33 and 37 patients Scholz et al, 1999; reported ‘no pain’ or ‘slight pain’ at dressing changes, respectively Kaspar et al, 2008; Spruce et al, 2016 In a 221-patient study, patients reported a decrease in wound pain over the course of the 4-week treatment period, from 64% of patients experiencing ‘intermediate’ to ‘high’ pain perception, to 19% of patients In a 20-patient observational study in patients with chronic wounds, 95% of patients reported some degree of wound pain at the commencement of the observation period (mean 15 days) and this value reduced to 35% Patient comfort In a 403-patient observational study in patients with a variety of ulcers, >90% of patients rated HARTMANN, 2010; the dressing ‘good’ or ‘very good’ on wearing and tolerability Spruce et al, 2016 In a 20-patient community-based study, patients reported that the dressing was comfortable to wear at 99% of dressing changes and there were no reports of the dressing moving out of place from the wound 4 w Box 2: Versions of HydroClean® plus Box 3: How HydroTac® works Box 4: Versions of HydroTac® HydroClean® plus A. … The wound was too painful to tolerate with HydroTac® compression therapy, and the patient had moderate exudate and fragile and dry periwound skin. Treatment The wound was too painful to tolerate compression therapy, and the patient had moderate exudate and fragile and dry periwound skin. …